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10.1038/onc.2011.447 Oncogene 151 WernerH.Lapkina-GendlerL.AchlaugL.NagarajK.SomriL.Yaron-SaminskyD.et al (2019)

Useful safety observations often include: Local tolerance: redness, irritation, swelling, or tenderness at the administration site Acute post-dose observations: changes in behavior, appetite, activity, or visible discomfort during the expected response window Pattern effects over time: whether repeated dosing appears to change tolerability or response consistency Protocol drift: missed timing windows, inconsistent preparation, or undocumented deviations that can confuse safety interpretation How dosing logic affects safety interpretation The why behind dosage matters most

Further investigations by Ng et al

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