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doi:10.2478/rjim-2021-0022

The first one involves irreversible damage to the ETC, possibly through TTC5 upregulation, resulting in ATP loss, increased mitochondrial superoxide production and caspases 3/7 activation, and subsequent apoptosis

Brito A, Verdugo R, Hertrampf E, Miller JW, Green R, Fedosov SN, Shahab-Ferdows S, Sanchez H, Albala C, Castillo JL, et al

Common and Serious Side Effects of Pemetrexed Disodium Like all chemotherapy agents, pemetrexed disodium side effects can range from mild to severe, affecting various body systems