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d- and l- where relevant are prohibited: Buprenorphine Dextromoramide Diamorphine (heroin) Fentanyl and its derivatives Hydromorphone Methadone Morphine Nicomorphine Oxycodone Oxymorphone Pentazocine Pethidine S9

Researchers have proposed that inhibiting NNMT may influence downstream metabolic pathways by altering nicotinamide utilisation and methyl donor availability