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Machine learning aided construction of the quorum sensing communication network for human gut microbiota

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International Journal of Pharmaceutical Sciences Review and Research 27: 254-260

Moreover, it has been shown that the phospholipase PNPLA1 belonging to the iPLA2 family in murine keratinocytes plays a crucial role in the biosynthesis of -O-acylceramide, a lipid component essential for the functioning of the skin barrier [61], and mutations in the PNPLA1 enzyme in both C- and N-terminal domains are associated with the development of autosomal recessive congenital ichthyosis (ARCI) [69, 70] causing abnormal lipid accumulation in fibroblasts and impairing the biosynthesis of -O-acylceramide [62]