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Peer review Peer review information Nature Reviews Neurology thanks Hlio Teive, Ludger Schls and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

In contrast, combining antioxidants with treatments that induce apoptosis through ROS-independent pathways may provide synergistic benefits and improve therapeutic outcomes

Repeated overdoses can also occur with self-harm intent (often termed staggered overdoses), and similarly carry an increased risk of hepatotoxicity when compared to acute self-harm overdoses *