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In mouse colitis models, engaging Siglec-F (such as with a Siglec-F antibody) leads to eosinophil apoptosis and has been shown to reduce colonic eosinophil numbers, although the impact on inflammation severity varied by model (some acute colitis models didn't improve, whereas chronic models or asthma models clearly benefited from eosinophil suppression) (205208)

Montgomery Jr., J

(1999) demonstrated this pattern in controlled studies using equivalent mass doses

Nevertheless, the protein levels of TNF and IL6 produced and secreted during the culture were significantly up-regulated (2-fold and 14-fold, respectively) in GFIPO medium