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Mitochondrial Quality Control in Cerebral Aging and Neurodegenerative Disorders While the dynamic equilibrium between mitochondrial energy production and quality control sustains cellular homeostasis in healthy states, aging disrupts this balance through progressive MQC failure

For example, liver assembles very low-density lipoprotein (VLDL) containing apolipoprotein B100 (apoB100) which delivers cholesterol to peripheral tissue and is eventually converted into LDL which is taken up by peripheral tissue via LDLR which may lead to several different outcomes including storage of cholesteryl esters 10,11,21,22,23,24,25,26,27,28,29

Iron overload is hypothesized to exacerbate this process through several pathways

This indicates that MMPTs exhibited better skin permeation properties than traditional liposomes