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Gonzalez LA, Gatch MB, Forster MJ, Dillon GH

NAFLD is associated with increased TCA flux in the liver (Rauckhorst et al., 2017, Satapati et al., 2012, Sunny et al., 2011), raising the question of whether NAFLD progression is accelerated by ER stress arising from this increased flux, and whether diminished hepatic TCA flux in mice lacking MPC activity protects the liver at least in part by alleviating or preventing ER stress

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Age, overall health, injury severity and chronicity, concurrent therapies , nutrition, sleep, and activity levels all influence outcomes