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chlorine, often used to disinfect conventional water, can react with organic material in the water to create chloroform, exposure to which can cause negative health effects

doi: 10.1186/s13054-020-03444-x 84 EkpenyongAEToepfnerNFiddlerCHerbigMLiWCojocGet al

40 Sympathetic dominance (ie, excessive fight-or-flight activation relative to resting nervous system activity) and the inability to mount a normal adaptive response to stress promote multiple symptoms, including pain, cognitive dysfunction, and feelings of stress

While lymphatic metastasis often follows arterial supply routes, hematogenous spread of gastrointestinal malignancies occurs via venous drainage rather than arterial supply