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A Brief History of GH Secretagogues The GH secretagogue story begins in the 1970s when Cyril Bowers discovered that small synthetic peptides based on enkephalin could release GH from pituitary cells without acting through opioid receptors

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Phase 2 clinical trials showed some positive outcomes, but these were not sufficiently significant over a treatment period of 7-10 days, leading to the halt of development [11, 12]

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