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33,34 In cartilage destined to be replaced by bone via endochondral ossification, chondrocytes, typically organized as morphologically discrete domains in growth plates, progressively mature and eventually undergo hypertrophy characterized by COL10A1 (encoding collagen X) expression

When tight junctions open inappropriately (triggered by gliadin in celiac disease, by cytokines in IBD, by dysbiotic bacterial products, or by other insults), the gut barrier becomes permeable to antigens that should remain in the lumen

This treatment response was maintained through 48 weeks of follow-up

KRAS pathway KRAS mutations represent one of the most prevalent and clinically notable genetic alterations in NSCLC, occurring in 2530% of cases, particularly among adenocarcinoma subtypes (85)