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doi:10.3390/molecules18010690 Emamat H, Tangestani H, Totmaj AS, Ghalandari H, Nasrollahzadeh J

It is commonly discussed in longevity and restorative medicine because of its potential connection to biological aging and sleep-wake regulation

Advanced research protocols sometimes explore combining GHRH analogs (such as sermorelin or tesamorelin) with GHRP peptides (such as ipamorelin or GHRP-6) to exploit a synergistic mechanism of GH release

Through the release of neuroimmune mediators such as vasoactive intestinal peptide (VIP), substance P, and calcitonin gene-related peptide (CGRP), the ENS modulates macrophage activation states, mast cell degranulation, and innate lymphoid cell activity 50,51,52,53 , which might calibrate local inflammatory tone during exercise-induced stress