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Contemporary biological theories are broadly categorised into programmed theories and damage- or error-based theories

Furthermore, matricellular proteins bind to receptors like integrins, Toll-like receptors (TLRs), and low-density lipoprotein-related receptors (LRPs), inducing critical changes in the cells of the niche (i.e., tubular epithelial cells, myofibroblasts, and inflammatory cells) such as adhesion, migration, proliferation, and differentiation [5]

In 2023 it was reported that the aging pigment lipofuscin can be broken down with the help of melanin and drugs through a newly discovered mechanism

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