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The Raun 1998 paper is an animal study

Its the mundane things: weight loss, exercise , regular sleep , stress reduction, avoiding cigarettes and excess alcohol, and having a great social network , says Dr

The protein aggregation and subsequent Fe-S cluster disruption induced by copper overload activate cellular protein quality control pathways, including the increased expression of molecular chaperones such as heat shock protein 70 (HSP70), which attempts to mitigate the proteotoxic burden (8,160)