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Tesofensine offers a compelling tool for athletes, competitors, and serious dieters who struggle with hunger, adherence, or energy during cutting phases

TABLE 1 Overview of the small molecule inhibitors targeting NNMT

A separate category, including CJC-1295 and Sermorelin, works through growth-hormone stimulation instead of appetite signaling: these peptides prompt the pituitary gland to release more of the body's own growth hormone, which supports fat metabolism and helps preserve lean muscle during a calorie deficit

The SURMOUNT data shows continuous weight loss through week 40 on average, with slowing but not stopping through week 72