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Additionally, autophagy plays an important role in CRPC [43, 44], and -ketoglutarate generated by glutamine metabolism functions via the TCA cycle and synthesizes biological macromolecules and acts as a cofactor for the histone demethylases JmjC-KDMs and members of the DNA demethylase TET family, participating in promoting histone and DNA demethylation processes and regulating gene expression [45]

Polyol pathway and redox balance in diabetes

Automaticity is the ability of the heart muscle cells to generate an electrical impulse

Administered at a dose of 2.5 M, the drug had minimal effects on proliferating glioblastoma cells (LN229 and A172) while demonstrating significant senolytic properties against the same cell lines subjected to senescence induction by temozolomide [106]