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Endophenotypes are intermediate, quantifiable biological traits that link observable clinical phenotypes to underlying genetic and molecular mechanisms ( Redox biology provides a compelling entry point for developing endophenotypes ( 3 Redox biology of the male reproductive system 3.1 Sources of ROS in testis, epididymis, and seminal plasma ROS generation is an inevitable outcome of cellular metabolism, and in the male reproductive tract, they play a dual role in sustaining physiological processes and driving pathological damage ( Figure 1 )