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Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/-arrestin2 and activating the cAMP-PKA signaling pathway in premenstrual irritability rats

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Consequently, the suggested combination approach holds the promise of enabling the use of lower doses of conventional chemotherapy, thereby mitigating undesirable toxic effects

Thatikonda, V, Lyu, H, Jurado, S, Kostyrko, K, Bristow, C, Albrecht, C, Alpar, D, Arnhof, H, Bergner, O, Bosch, K, Feng, N, Gao, S, Gerlach, D, Gmachl, M, Hinkel, M, Lieb, S, Jeschko, A, Machado, AA, Madensky, T, Marszalek, ED, Mahendra, M, Melo-Zainzinger, G, Molkentine, JM, Jaeger, PA, Peng, D, Schenk, RL, Sorokin, A, Strauss, S, Trapani, F, Kopetz, S , Vellano, CP, Petronczki, M, Kraut, N, Heffernan, TP, Marszalek, JR, Pearson, M, Waizenegger, IC, Hofmann, MH