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The kinetics of desensitization of the NMDAR responses were determined by fitting the glutamate/glycine-evoked responses at V m 60 mV to a double-exponential function in order to determine the weighted time constant ( w ,des):where A f and f are the amplitude and time constant of the fast component of desensitization and A s and s are the amplitude and time constant of the slow component of desensitization

However, irritation depends on the ability of geraniol to penetrate into the skin