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Cisplatin exerts its cytotoxic effects through a complex interplay of molecular mechanisms, primarily by coordinating DNA to form platinumDNA adducts, resulting in DNA damage, mitochondrial dysfunction, reactive oxygen species (ROS) generation, modulation of cell death pathways and subsequent apoptosis [7]

To measure their actual stiffness, the gels were immersed in PBS and force was measured on a NanoWizard three NanoOptics atomic force microscope (JPK Instruments, Berlin, Germany)

DSIP may be discussed in relation to sleep signaling, neurochemistry, and stress biology, but no large modern randomized controlled trials or meta-analyses were identified to validate these mechanisms as reliable human outcomes

Certain antidepressants such as Prozac might be used once to counter the psychological side effects of quitting duloxetine