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doi: 10.1158/2326-6066.Cir-17-0716 96 WanCSunYTianYLuLDaiXMengJet al

These synthetic compounds are referred to as glycomimetics because they mimic the structure and biology of natural product glucans

The expression level of HO-1 is notably reduced in the EAOC group in comparison to the benign OE group, as indicated by the diminished presence of 8-hydroxy deoxyguanosine (8-OHdG) in the fluid

As such, fentanyl may act on peripheral structures, brain regions without a bloodbrain barrier, and brain structures within the blood brain barrier 15,20