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Female mice were selected as the primary sex for our models as previous studies examining vitamin B12 effects on mitochondrial function were conducted exclusively in males [16, 17], necessitating evaluation of sex-specific responses

(i) For the applicable period beginning October 1, 2025, and subsequent applicable periods, CMS will exclude from the total number of units determined under paragraph (a) of this section units for which a manufacturer provided a discount under the 340B Program (340B units) as follows: (A) For the applicable period beginning October 1, 2025, 340B units will be excluded from the total number of units dispensed for claims with a date of service on or after January 1, 2026

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Informed by these studies, an alternative and novel hypothesis for the etiology of ASD implicates autoimmune pathology involving a maladaptation of the immune system in the CNS [133]