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The review also noted that GHK-Cus copper complexation ability raises Cu2+ penetration rates across the stratum corneum, and documented the development of formulation innovations including the TriHex peptide system that combine GHK-Cu-type tripeptides with hexapeptides to produce synergistic upregulation of regenerative genes and suppression of aberrant collagen deposition

Otter S, Lammert E

An allergic reaction to iron supplements may also be triggered by other ingredients, such as tartrazine (a type of yellow food coloring), sulfites, or milk, soy, or wheat byproducts

presented a work based on organoidderived proximal tubule epithelial cells (OPTEC)-on-chip, providing a more sensitive predictor of nephrotoxicity compared to traditional models based on immortalized PTECs (166)