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What to expect: Maximum improvement in sleep architecture and sleep quality Strongest circadian rhythm reinforcement the distinction between deep nighttime sleep and alert daytime wakefulness is maximized Full HPA axis modulation effects Optimal physical recovery and daytime energy The narcolepsy case study by Schneider-Helmert showed that DSIP's effects on sleep-wake rhythmicity were most pronounced with sustained treatment compressing the sleep period while enhancing sleep quality within it, and reducing daytime sleep intrusions (Schneider-Helmert, 1984)

4-OH-E 1 4-Hydroxyestrone (4-OH-E 1 ) is an endogenous metabolite of estrone that can inhibit PDIs catalytic activity [39]