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Introduction The liver is a major site of metabolism and detoxification of drugs and xenobiotics in the human body ( CYP2E1 ) increases, with an increase in the formation of a highly reactive toxic intermediate metabolite, N-acetyl-p-benzoquinone imine (NAPQI) (Wang et al., 2017)

As an important antioxidant enzyme, CAT has a role in protecting chondrocytes by reducing TNF--induced apoptosis [145]

C., Tseng, W

Patients with hypothyroidism have increased intestinal permeability and leaky gut phenomenon, which makes the metabolic products of bacteria such as LPS and bacterial fragments easily translocate into the circulatory system, thus activating innate immunity (Tomov et al., 2005)