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Oxidation of fatty acids Oxidation of fatty acids is controlled by PPAR and occurs mainly in the mitochondria, providing a source of energy to generate ATP especially when circulating glucose concentrations are low [14, 77,78,79,80,81]

Future research directions should include in-depth mechanistic exploration and the development of more effective, safer clinical interventions targeting the ferroptosis pathway in cardiovascular disease

Research indicates that iron overload can lead to increased ROS production, which in turn disrupts mitochondrial membrane potential and promotes cell death pathways such as ferroptosis

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