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KPV blocks NF-kB activation, suppressing the production of pro-inflammatory cytokines including TNF-alpha, IL-1beta, and IL-6

Patients who experience significant side effects at any dose can remain at that dose longer (6-8 weeks) before escalating, or step back to the previous dose temporarily before attempting escalation again

The KPV peptide from the bottom layer was rapidly released within 1 3 d to exert an anti-inflammatory effect during the early stages of wound healing, while the EGF from the middle and upper layers was continuously released over 7 d to promote subsequent production of collagen [326]

After staining, cells were resuspended in 150 l FACS buffer and washed once in 200 l FACS buffer