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Based on in silico predictions, these phases show high correlation with the pre-defined cycling state of the analyzed endometrial biopsies (i.e

There was also a significant increase in urine of m+3 orotate, which is derived from pyruvate carboxylation to oxaloacetate, demonstrating another mechanism by which Cse / mice can waste carbon in the absence of CoA (Extended Data Fig

However, a higher incidence of hemorrhage was observed in subjects with moderate hepatic impairment than in normal subjects [see Use in Specific Populations (8.7)]