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SM: Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Resources, Writing review & editing

When adverse factors disrupt the brains homeostatic repair mechanisms, physiological aging may progress to pathological aging, ultimately leading to neuronal loss and neurodegeneration (Park and Reuter-Lorenz, 2009

Vascular lesions: Such condition is caused by injury to the vascular endothelium and may be caused by chemotherapeutic agents [52], bush tea [ Crotalaria spp .] and anabolic steroids [53]

Importantly, iodoacetamide (IAA, a known thiol-reactive compound) was not able to oxidize roGFP when cells were exposed to non-lethal or subtoxic concentrations of this compound, indicating that an electrophilic attack on roGFP is not sufficient to cause a spectral change consistent with its oxidation (Supplementary Fig