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Genetic mutations like MTHFR: Methylenetetrahydrofolate reductase (MTHFR) is a gene that converts folate into a form that the body can use

Peptides affecting similar pathways may produce diminishing returns rather than synergy

Neurons undergoing ferroptosis release damage-associated molecular patterns (DAMPs) such as HMGB1, ATP, and lipid peroxidation products, which activate microglia and drive them toward a pro-inflammatory phenotype

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