methionine precursor glutathione Homocysteine metabolism and (GSH) synthesis. The Cysteine metabolic circuitries: druggable targets

Ethics declarations Conflict of interest Nicola McCarthy is an employee of Horizon Discovery

doi:10.1016/j.jacc.2017.10.024 Harrington, Jennifer et al

A similar role is attributable to ubiquinolcytochrome c reductase hinge (UQCRH), another subunit of complex III that is overexpressed in lung adenocarcinoma 47 and in hepatocellular carcinoma

3 Brief description of important metabolic pathways 3.1 The tricarboxylic acid (TCA) cycle (also called Krebs cycle or citric acid cycle) The TCA cycle takes place within the mitochondrial matrix and is a central regulator of energy production by oxidation of acetyl-coenzyme A (acetyl-CoA) derived from the metabolism of carbohydrates (and more specifically from glucose-derived pyruvate), fatty acids as well as proteins ( 2 the reduced form of flavin adenine dinucleotide (FAD) -, which will enter the oxidative phosphorylation pathway to further generate energy in the form of ATP (Martnez-Reyes and Chandel, 2020)