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In 5xFAD mice, anxiety-like behaviors typically begin at 5 months old, with males showing more profound symptoms (Dong et al., 2020

Oxidative stress and generated free radicals which mainly occur in the highly oxidative intracellular microenvironment surrounding the neurons and glial cells, are associated with brain ageing and brain injury [24]

Chronic administration of apocynin, a NOX inhibitor antioxidant, following pilocarpine-induced SE did significantly increase neural survival (Malkov et al., 2019)