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Interestingly, inflamed mucus from IBD patients show a significant reduction of dopamine, mainly related to reduced dopamine uptake and the number of sympathetic fibers interacting with the intestinal wall ( Reduced intestinal dopamine levels [140 pg/ml in healthy individuals;45 pg/ml in CD and UC patients ( Conversely, high concentrations of dopamine in the intestine of healthy people can stimulate D2R, promoting the production of IL-10, inhibiting intestinal motility and ulcer development ( Rheumatoid Arthritis Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by persistent inflammation of the joint synovium ( via affecting osteoclasts differentiation or the secretion of pro-inflammatory cytokines

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Whether activating HGF/c-Met/mTOR signaling pathway directly regulates NGF expression by affecting downstream transcription factors remains unclear