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Interestingly, even in conditions of reduced GLP-1 secretion observed in individuals with obesity and T2D, its receptor-mediated effects remain intact

Navarro and Mora [25], building upon the hypothesis proposed by Pickup and Crook [26], suggest that diabetes is transitioning from a metabolic disorder to a genuine inflammatory pathology, where prolonged and improper activation of the immune system contributes to the development and progression of the disease