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Patients with Chronic Pulmonary Disease: Hydrocodone bitartrate and acetaminophen tablet-treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages of hydrocodone bitartrate and acetaminophen tablets (see WARNINGS, Life-Threatening Respiratory Depression)

Gosain A, DiPietro LA

Poor coupling of the P450 catalytic cycle leads to continuous production of ROS, which affects signaling pathways and other cellular functions [106]

Up to 4 areas can be treated per session with a loss of up to 24 percent of fat from these areas