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Wensing KU, Ciarimboli G

Regulation of apoptosis signal-regulating kinase 1 in redox signaling

* Plasma samples were collected for all 53 participants, whereas urine samples were collected for 51 of the 53 participants (subjects 19 and 21, both females, did not provide urine samples)

3.1 Cellular consequences of macrophage lipotoxicity Excessive intracellular accumulation of FFAs, termed lipotoxicity, can promote pro-inflammatory responses, disrupt cellular homeostasis, induce organelle dysfunction, and ultimately induce cell death in macrophages (69, 70, 80)