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However, the physiological substrates of OCTN1 are still matter of discussion (Pochini et al., 2019 and Table 1)

Thus, metabolic reprogramming directly regulates the methylation writers and erasers. Conversely, DNA methylation acts as a stable epigenetic memory that consolidates and amplifies aberrant metabolic states, forming an epigenetic metabolism feedback axis

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Chung and colleagues study the use of tadalafil for treatment of PD in human subjects