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170 ScheperjansF.AhoV.PereiraP

Frontiers in Nutrition 10

Evidence of Parkin/PINK1-mediated mitophagy from patient iPSC-derived neurons Although mutations in Parkin or PINK1 were found to compromise mitophagy in cultured cells and animal models, direct pathological evidence is still lacking if the same mutations would impair mitophagy and if such defect is the key factor for the loss of DA neurons in vivo or in PD patients 49