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Metabolic Significance ERRs are master regulators of cellular energy metabolism, controlling the expression of genes involved in fatty acid oxidation, oxidative phosphorylation, the citric acid cycle, and mitochondrial biogenesis

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333 It is reported that LRRK2 G2019S dopaminergic neurons exhibit a decreased NAD + pool and a reduced sirtuin deacetylase activity, correlating with elevated acetylation of sirtuin substrates p53, -tubulin and SOD2