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However, glutathione (GSH) modified proteins are also formed under a circumstance without significant change in GSSG level (1112), and a radical-initiated process has therefore also been proposed (3)

Loukas M, Curry B: Right atrial aneurysm

The C-4 region of kinases is a hotspot for kinase regulation, and here we have demonstrated the bi-directional allosteric control of Aurora-A kinase by its native partners at this region of the kinase surface