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Reactive oxygen species can oxidize cellular GSH, leading to the loss of intracellular redox homeostasis and activation of the apoptotic signaling cascade

The second DMR is distant from the transcriptional initiation site of the PIGZ gene but partially overlaps with a Histone H3 lysine 27 acetylation (H3K27ac) mark (associated with active enhancer function) in the human immortalized myelogenous leukemia cell line K562

The objective of our study is to evaluate the characteristics and outcomes of donated organs subjected to machine perfusion versus no perfusion, and to further stratify normothermic versus hypothermic perfusion

Chemical modifications, such as the substitution of -Br, -Cl, -CH3, and -NO2 groups onto natural flavonoids, modulate the gut microbiota by slowing harmful bacteria and promoting beneficial bacteria (Perz et al