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Med 5 , 10321038 (1999)

Because MTHFR gene variations impair the bodys ability to convert B vitamins, methylated forms of B vitamins are considered the most bioavailable as they dont need any conversion by the body Consider high doses: you might need significant doses of methylcobalamin to treat a deficiency

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The ideal outcome for future regenerative therapies is to be able to fully replace any damaged and diseased tissue with a substitute that has the capability to restore physiological function throughout the remainder of the patients lifetime