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Iron overload-induced ferroptosis has been increasingly recognized as a critical contributor to the pathogenesis of multiple fibrotic diseases, including hepatic fibrosis [20], renal fibrosis [21], radiation-induced intestinal fibrosis [22], myocardial fibrosis [23], and PF [24]

StekovicSHoferSJTripoltNAonMARoyerPPeinLet al

A positive outcome begins when both parties, the patient and the provider, have trust in one another and confidence in the direction of care

The mice were intraperitoneally injected (i.p.) with D-gal at a dose of 500 mg/kg/day (0.1 mL/10 g) for 7 weeks, except for the mice in the CG who received an equal volume of 0.9% normal saline