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Vitamin B12 deficiency has been linked to fatigue, tingling or loss of feeling in the extremities, irritability, memory impairment, depression, anemia, irritable bowel syndrome (IBS), constipation, poor wound healing, dry or damaged looking skin, and neurological disorders

Despite being originally classified as a non-essential amino acid [32] in healthy individuals [33], abundant evidence suggests that glutamine is essential in specific stress situations such as severe illness, trauma, and overtraining [9, 34,35,36,37,38]

Conventional DCs include cDc1 and cDc2 (intracellular antigen presentation through major histocompatibility complex I [MHC-I]/CD8+ T cell and MHCII/CD4+ T cells, respectively) while pDCs are associated with antitumor and antiviral response via the production of interferon (IFN)- (87)