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Data For the present study, publicly available RNA-seq data from The Cancer Genome Atlas programme (TCGA patient data (GEO: GSE62944) [23], and the Cancer Cell Line Encyclopaedia (CCLE)) were combined with IN-HOUSE generated RNAseq data according to Table 1 and Supplementary File 1

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Treatment Options: Relief and Recovery For Skin Allergies: Antihistamines: To block allergic responses Topical corticosteroids: Reduce inflammation and redness Avoidance of triggers: Crucial for long-term control For Fungal Infections: Topical antifungal creams/powders: First-line treatment Oral antifungal medication: For stubborn or widespread infections Lifestyle changes: Keeping skin dry and clean Always follow your dermatologists instructions regarding medication use and duration

Evidence indicates retinol's role in photodamage modeling helps elucidate mechanisms of cellular senescence and mitochondrial dysfunction in skin aging pathways