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3 Brief description of important metabolic pathways 3.1 The tricarboxylic acid (TCA) cycle (also called Krebs cycle or citric acid cycle) The TCA cycle takes place within the mitochondrial matrix and is a central regulator of energy production by oxidation of acetyl-coenzyme A (acetyl-CoA) derived from the metabolism of carbohydrates (and more specifically from glucose-derived pyruvate), fatty acids as well as proteins ( 2 the reduced form of flavin adenine dinucleotide (FAD) -, which will enter the oxidative phosphorylation pathway to further generate energy in the form of ATP (Martnez-Reyes and Chandel, 2020)

Grnde dies erforderlich machen Wirkung Wirkung Glutathion (abgekrzt auch GSH) ist ein Tripeptid, das aus den drei Aminosuren Glutaminsure, Cystein und Glycin aufgebaut ist

Willis et al

Therefore, our findings suggest that pyroptosis of synovial macrophages plays a role in inducing inflammation in synovial chondrocytes and targeting synovial macrophages may be a potential therapeutic strategy for OA management