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Melanocortin-Derived Tripeptide KPV Has Anti-Inflammatory Effects in Murine Models of IBD Inflammatory Bowel Diseases (2008) Demonstrated that KPV reduced weight loss, histologic damage, and myeloperoxidase (MPO) activity in two well-established mouse models of colitis (DSS and CD45RB^hi transfer), even in mice lacking functional melanocortin-1 receptor (MC1R), indicating receptor-independent mechanisms