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This behavior of the GS flux is caused by the competition between the higher inhibition of GS and GCL by GSH and the higher stimulation of GCL by estradiol [Figure 2]

Nat Protoc 2, 18021810 (2007)

J Immunol 179(3):19131925

This study implies that changes in mitochondrial morphology caused by EBV- encoded oncogenes promote mitochondrial function and reprogramming metabolism