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Hyperammonaemia-induced Skeletal Muscle Mitochondrial Dysfunction Results in Cataplerosis and Oxidative Stress

Sustained IGF-1 elevation is a theoretical concern for occult malignancy and for proliferative retinopathy, and most research protocols include a baseline and a 12 week IGF-1 measurement with dose reduction or discontinuation triggers at greater than 2 standard deviations above the age-matched mean

This could be due to impaired SREBP2 translocation to the nucleus in rSCC-61 cells a hypothesis supported by the cumulative action of insulin induced genes (INSIG1/2) and 24-OH oxysterol, which are both significantly higher in rSCC-61 ( Figure S6B )