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The survival and migration of neural stem cells were also reported to be regulated by IGF-1R when transplanted into an injured spinal cord, and their survival and migration could be augmented through treadmill training (Hwang et al., 2018)

10.1007/978-1-4614-3704-8_19 467 PermyakovE

They propose a staging system that takes into account these anchors, and starts from Stage 0, preclinical disease, defined by the presence of fully penetrant SNCA variants

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